会计学1自组装单分子薄膜自组装单分子薄膜图图1 1 自组装单层膜结构示意图自组装单层膜结构示意图自组装单分子薄膜自组装单分子薄膜SAMs 的优点的优点n n制备方法简单SAMs 的优点的优点n n不受基底形状的限制：无论曲面还是平面 纳米球SAMs 的优点的优点n n与基底结合牢固，稳定性高，自组装分子一般都是与基与基底结合牢固，稳定性高，自组装分子一般都是与基底以化学键结合，分子链间主要以范德华力相互作用；底以化学键结合，分子链间主要以范德华力相互作用；n n薄膜结构灵活可控，从分子和结构设计入手，可同时在薄膜结构灵活可控，从分子和结构设计入手，可同时在分子水平和材料水平上实现对薄膜结构的调控分子水平和材料水平上实现对薄膜结构的调控 自组装单分子薄膜为研究表面现象提供了一个理想的模型，如边界润滑、生物传递、表面能的控制等，它还在摩擦学、材料学、电子学、非线性光学等诸多领域有重要的应用基础研究价值SAMs的种类的种类n n长链酸类自组装单层膜长链酸类自组装单层膜长链酸类自组装单层膜长链酸类自组装单层膜 图图 3 Al2O3及及AgO表面上长链羧酸单层膜的结构示意图表面上长链羧酸单层膜的结构示意图SAMs的种类的种类n n烷基硫醇类化合物在金属表面形成的烷基硫醇类化合物在金属表面形成的烷基硫醇类化合物在金属表面形成的烷基硫醇类化合物在金属表面形成的SAMs SAMs SAMs SAMs 图 4 金基底上含有奇、偶数目亚甲基长直链硫醇的结构示意图 SAMs的种类的种类n n有机硅烷类有机硅烷类有机硅烷类有机硅烷类SAMsSAMsSAMsSAMs 图 5 基底与单层薄膜界面上聚硅氧烷的结构示意图。
SAMsSAMs在在分子电子学分子电子学中应用中应用 分子电子学分子电子学研究的是分子水平上的电子学，其目标是用单个分子、超分子或分子簇代替硅基半导体晶体管等固体电子学元件组装逻辑电路，乃至组装完整的分子计算机SAMsSAMs在在分子电子学分子电子学中应用中应用SAMs在在生物学生物学中应用中应用常用仪器常用仪器n n扫描探针显微镜（扫描探针显微镜（扫描探针显微镜（扫描探针显微镜（SPMSPMSPMSPM）云母的原子云母的原子STM图图原子力显微镜AFM常用仪器常用仪器椭圆偏光测厚仪椭圆偏光测厚仪n n衰减全反射红外光谱衰减全反射红外光谱衰减全反射红外光谱衰减全反射红外光谱n n反射红外光谱反射红外光谱反射红外光谱反射红外光谱常用仪器常用仪器常用仪器常用仪器n nX X光电子能谱（光电子能谱（光电子能谱（光电子能谱（XPSXPS）XPS，全称为X-ray Photoelectron Spectroscopy，是一种基于光电效应的电子能谱，它是利用X射线光子激发出物质表面原子的内层电子，通过对这些电子进行能量分析而获得的一种能谱博士论文工作博士论文工作博士论文工作博士论文工作自组装有机薄膜的内在结构与摩擦学性能自组装有机薄膜的内在结构与摩擦学性能自组装有机薄膜的内在结构与摩擦学性能自组装有机薄膜的内在结构与摩擦学性能 含酰胺键自组装单分子薄膜含酰胺键自组装单分子薄膜 ITPOA 预水解48h 环己烷稀释，沉积24hSY Song et al Langmuir 2006,22,6010-6015.制备过程结构示意图SY Song,et al The Journal of Physical Chemistry C,2008,112,3805-3810.含酰胺键自组装单分子薄膜含酰胺键自组装单分子薄膜 II含酰胺键自组装单分子薄膜含酰胺键自组装单分子薄膜含酰胺键自组装单分子薄膜含酰胺键自组装单分子薄膜 IIIIIIDAC18DAC18薄膜的理想结构。
薄膜的理想结构疏水性，承载能力疏水性，承载能力降低摩擦系数降低摩擦系数氨基表面密度高，氨基表面密度高，双层氢键的形成，双层氢键的形成，提高摩擦稳定性提高摩擦稳定性原子力形貌图原子力形貌图原子力形貌图原子力形貌图(a)(b)RMS:0.15 nmRMS:0.20 nmDA和和DAC18膜表面的原子力形貌图，扫描范膜表面的原子力形貌图，扫描范围围500nm500nm，竖直方向高度范围，竖直方向高度范围2nm衰减全反射红外光谱衰减全反射红外光谱衰减全反射红外光谱衰减全反射红外光谱DA膜和膜和DAC18膜的衰减全反射红外光谱膜的衰减全反射红外光谱SY Song et al Langmuir,2008,24,105-109.新加坡国立大学博后工作新加坡国立大学博后工作Single-Molecule Force and Fluorescence Lab R.Liu et al Biophysical Journal 96(9),3810-3821(2009)在河南大学的科研在河南大学的科研n n仿关节软骨结构水凝胶薄膜聚合物刷水凝胶表面引发原子转移自由基聚合POMAPOMA聚合物膜在氨基自组装膜表面的形成示意图。
聚合物膜在氨基自组装膜表面的形成示意图SY Song et al Applied Surface Science 2011,257,10254.n nPOMA聚合物薄膜pHpH敏感聚合物胶束敏感聚合物胶束Nanomedicine Nanomedicine is the application of nanotechnology in Nanomedicine is the application of nanotechnology in medicine,including to cure diseases and repair damaged medicine,including to cure diseases and repair damaged tissues such as bone,muscle,and nervetissues such as bone,muscle,and nerveKey Goals for NanomedicineKey Goals for Nanomedicine To develop cure for traditionally incurable diseases(e.g.cancer)through the utilization To develop cure for traditionally incurable diseases(e.g.cancer)through the utilization of nanotechnologyof nanotechnology To provide more effective cure with fewer side effects by means of targeted drug To provide more effective cure with fewer side effects by means of targeted drug delivery systemsdelivery systemsNanotechnology in Health Care Thermal ablation of cancer cells assisted by nanoshells coated with metallic layer and an external energy source National Cancer InstituteThermal ablation of cancer cellsNanoshells have metallic outer layer and silica coreSelectively attracted to cancer shells either through a phenomena called enhanced permeation retention or due to some molecules coated on the shellsThe nanoshells are heated with an external energy source killing the cancer cellsNanotechnology in Health Care TreatmentTargeted drug deliveryNanoparticles containing drugs are coated with targeting agents(e.g.conjugated antibodies)The nanoparticles circulate through the blood vessels and reach the target cellsDrugs are released directly into the targeted cellsTargeted drug delivery Targeted drug delivery using a multicomponent nanoparticle containing therapeutic as well as biological surface modifying agents Mauro Ferrari,Univ.of Cal.BerkleyNanotechnology in Health Care The microfluidic channel with nanowire sensor can detect the presence of altered genes associated with cancer J.Heath,Cali.Insti.of TechnologyThe nanoscale cantilever detects the presence and concentration of various molecular expressions of a cancer cell A.Majumdar,Univ.of Cal.at BerkeleyNanotechnology offers tools and techniques for more effective detection,diagnosis and treatment of diseasesDetection and DiagnosisLab on chips help detection and diagnosis of diseases more efficiently Nanowire and cantilever lab on chips help in early detection of cancer biomarkersPotential Risks of Nanotechnologyn nHealth issuesn nNanoparticles could be inhaled,swallowed,absorbed through skin,or Nanoparticles could be inhaled,swallowed,absorbed through skin,or deliberately injecteddeliberately injectedn nCould they trigger inflammation and weaken the immune system?Could Could they trigger inflammation and weaken the immune system?Could they interfere with regulatory mechanisms of enzymes and proteins?they interfere with regulatory mechanisms of enzymes and proteins?n nEnvironmental issuesn nNanoparticles could accumulate in soil,water,plants;traditional filters are Nanoparticles could accumulate in soil,water,plants;traditional filters are too big to catch themtoo big to catch themn nNew risk assessment methods are neededn nNational and international agencies are beginning to study the risk;results National and international agencies are beginning to study the risk;results will lead to new regulationswill lead to new regulationsToxicity of Nanomaterialsn nSiO2纳米颗粒能够降低支气管癌原细胞的发育能力，并且细胞能够降低支气管癌原细胞的发育能力，并且细胞的发育能力随剂量和暴露时间增加而降低的发育能力随剂量和暴露时间增加而降低n n量子点（QDs）会诱导普遍的酰基化反应，致使细胞内会诱导普遍的酰基化反应，致使细胞内DNADNA结构出现紊乱，并在一定程度上破坏线粒体的功能。
结构出现紊乱，并在一定程度上破坏线粒体的功能n n碳纳米材料（碳纳米管，富勒烯）：体内无法体内无法清除的长碳纳米管诱发小鼠体内吞噬细胞融合的细胞因子，导致肉芽清除的长碳纳米管诱发小鼠体内吞噬细胞融合的细胞因子，导致肉芽瘤的生成；富勒烯则会诱发脂质过氧化以及细胞膜结构的破坏，使产瘤的生成；富勒烯则会诱发脂质过氧化以及细胞膜结构的破坏，使产生细胞毒性生细胞毒性n n纳米材料对环境生物的毒性寄寄 语语 Life is like a box of chocolates,.You never know what youre gonna get.-Forrest Gump阿甘正传 谢 谢！。